SAMe, the acronym for S-adenosyl-L-methionine, is a compound found naturally in the human body. Discovered in the 1950s as a derivative of the amino acid methionine, it maintains cell membranes, in addition to, producing and regulating hormones. It is not found naturally in foods, therefore a synthetic version is required to normalize inadequate levels.
SAMe may help depression due to its antidepressant effects, specifically mechanisms increasing levels of serotonin, dopamine, and norepinephrine.
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